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. 2014 Jul 1;4:5511. doi: 10.1038/srep05511

Figure 6. Cisplatin modulates BTG2 expression via the dwonregulation of NFκB activity in PC-3 cells.

Figure 6

(a) Luciferase activity of NFκB reporter vectors-transfected PC-3 cells treated with indicated concentrations of cisplatin. (b) Luciferase activity of PC-3 cells cotrasfected with BTG2 reporter vectors along with IκB or MAP3K14 expression vectors. (c) Luciferase activity of wild-type BTG2 reporter vectors (pGL3-BTG2) - or BTG2 reporter vector with mutated NFκB response element (pGL3-NFκBm) -transfected PC-3 cells cotransfected with pcDNA3 (white bars) or IκB expression vector (black bars). (d). Luciferase activity of wild-type BTG2 reporter vectors (pGL3-BTG2)- or BTG2 reporter vector with mutated NFκB response element (pGL3-NFκBm)-transfected PC-3 cells treated with (black bars) or without (white bars) 20 μM cisplatin. Each value is the % in relation to the control group. Data are presented as the mean percentage ± SE (n = 6). (*P < 0.05, **P < 0.01).