Figure 2. Possible roadmaps of mixing drugs and copolymers to obtain IRN-loaded PLGA-PEG-PLGA aqueous solution.
Here, the “drug” IRN is moderately soluble in water, and the “polymer” PLGA-PEG-PLGA is amphiphilic and sensitive to temperature in water; “RT” and “high temperature” refer to room temperature (approximately 20°C) and 85°C, respectively.