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. 2014 Jul 1;4:5473. doi: 10.1038/srep05473

Figure 7. Active lactone fraction of IRN in the thermogel.

Figure 7

(a) HPLC chromatogram of IRN under indicated conditions. The complete lactone form was obtained under an acid condition (pH 3); the complete carboxylate form was obtained under a base condition (pH 10). The equilibrium lactone fraction was much higher in the thermogel than that in PBS only. (b) Lactone fractions of IRN in both PBS and thermogel (20 wt% PLGA-PEG-PLGA with PBS as medium) at 37°C at indicated time points (n = 3). (c) pH values in the thermogel and outer PBS.