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. 2014 Jul 1;8:60. doi: 10.3389/fnana.2014.00060

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Copyright © 2014 Gaykema, Nguyen, Boehret, Lambeth, Joy-Gaba, Warthen and Scott.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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HFD consumption, but not food-driven exploration, substantially increases Fos in the paraventricular nucleus (PVN) and the arcuate nucleus (Arc) of the hypothalamus when compared to the control group (exposed to empty petri dish). Representative photomicrographs are shown of the PVN (A–C) and the Arc (E–G) from control (A,E), HFD fed (B,F) and animals following food driven exploratory behavior (C,G). HFD feeding led to a significant increase in Fos in the PVN (D, **p < 0.05) and the Arc (H, *p < 0.05). No change in fos expression was observed in the PVN of the food driven exploratory behavior group (D, dish [HFD]) while a small, yet statistically insignificant increase was noticeable in the Arc (H, +). Scale bars in A,E = 100 μm and also applies to panels B,C and F,G.