Table 1. The common features and differences between Ig produced by cancer cells and Ig produced by B cells.
Ig produced by cancer cells | Ig produced by B cells | ||
---|---|---|---|
Heavy chain classes | α, γ, µ, ε and δ | ||
Light chain types | Only κ-chain was found | κ- or λ-chain | |
Genetic processing | V(D)J is rearranged | ||
Germline configuration of C region Lacking V regionSpecial rearrangement pattern | Normal V(D)J rearrangement and class switching under control | ||
Transcription | Regulated by cis-acting elements and transacting factors | ||
J1-5 all transcribed | One of J1-5 is chosen to be transcribed | ||
Protein expression | Expression level is low | Expressing level is high | |
Protein structures | Unknown | Free antibody tetramer, IgA dimer, IgM pentamer | |
Post translational modification | N-acetyl and N-glycoyl neuraminic acid↑ N-acetylglucosamine↓ | N-glycans attached to Fc region modulates Ig's biological activity | |
Function | Favoring tumor growth | Specific antigen receptor; combine Fc receptor; activate complement system |
Abbreviation: Ig, immunoglobulin.