Skip to main content
. Author manuscript; available in PMC: 2014 Jul 1.
Published in final edited form as: Curr Med Chem. 2012;19(9):1346–1359. doi: 10.2174/092986712799462612

Fig. (2).

Fig. (2)

Diagram of the possible consequences of PSMA folate hydrolase activity in prostate cancer cells. Scavenged poly-γ-glutamyl folate substrates could feed nearby or interacting mGluR1/5 or NMDARs with released glutamates, maintaining both the downstream activation of NF-γB and raising intracellular calcium levels indirectly through mGluR5 signaling or directly through NMDAR channel opening. Small amounts of glutamate might be beneficial while large amounts of glutamate could cause excitotoxicity.