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. Author manuscript; available in PMC: 2014 Jul 1.
Published in final edited form as: J Bone Miner Res. 2014 May;29(5):1141–1157. doi: 10.1002/jbmr.2120

Fig. 1.

Fig. 1

Jck mice develop high-turnover bone disease during progression of chronic kidney disease. (A) Serum BUN levels, a marker of kidney function are elevated progressively in jck mice whereas no change is observed in WT mice. (B) Serum PTH levels are significantly elevated at 12 weeks and further increased at week 16. (C) Number of osteoclasts is significantly increased in jck mice. (D) Representative TRAP staining shows significant increases in N. OC/BS (%) at 16 weeks of age. (10 X objective lens). Results are expressed as mean ± SEM. * indicates p < 0.05 compared with age-matched WT mice by t-test (n ≥ 10)