Table 1.
Serum biochemistry values of jck mice after 4 and 7 weeks of treatment
| 4 week treatment | 7 week treatment | |||||
|---|---|---|---|---|---|---|
|
|
||||||
| PBS | 1D11 (2 mg/kg) | 1D11 (5 mg/kg) | PBS | 1D11 (2 mg/kg) | 1D11 (5 mg/kg) | |
| BUN (mg/dl) | 53 ± 2 | 55 ± 3 | 62 ± 4 | 77 ± 3 | 72 ± 7 | 93 ± 8 |
| Creatinine (mg/dl) | 0.26 ± 0.02 | 0.27 ± 0.02 | 0.24 ± 0.01 | 0.27 ± 0.07 | 0.26 ± 0.05 | 0.29 ± 0.02 |
| Phosphate (mg/dl) | 11.1 ± 0.6 | 10.1 ± 0.6 | 8.8 ± 0.4* | 11.2 ± 0.7 | 9.8 ± 0.7 | 11.1 ± 0.9 |
| Calcium (mg/dl) | 8.7 ± 0.2 | 8.6 ± 0.2 | 8.9 ± 0.2 | 7.1 ± 0.2 | 7.6 ± 0.1 | 6.8 ± 0.2 |
| FGF23 (pg/ml) | 27967 ± 7442 | 39979 ± 11067 | 15706 ± 2777 | 8818 ± 2413 | 9369 ± 2705 | 9813 ± 2104 |
| PTH (pg/ml) | 935 ± 132 | 968 ± 143 | 707 ± 119 | 2190 ± 335 | 1828 ± 240 | 1745 ± 334 |
| 1,25-(OH)2D (pg/ml) | 239 ± 13 | 242 ± 12 | 233 ± 14 | 365 ± 38 | 448 ± 37 | 351 ± 37 |
| Osteocalcin (ng/ml) | 115 ± 9 | 72 ± 6* | 94 ± 10 | 79 ± 10 | 60 ± 8* | 41 ± 3* |
| CTX (ng/ml) | 27 ± 2 | 27 ± 2 | 28 ± 2 | 37 ± 4 | 27 ± 1 | 23 ± 2* |
| P1NP (ng/ml) | ND | ND | ND | 30 ± 6 | 23 ± 4 | 11 ± 2* |
Data are shown as mean ± SEM.
*
indicates p < 0.05 versus PBS treated age-matched jck mice by one-way ANOVA and Tukey’s multiple comparison test (n ≥ 12 in the 4 week treatment groups; n ≥ 8 in the 7 week treatment groups).
ND, not determined.