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Relationships between level of interleukin-1R (IL-1R) modulation and (a) β-cell rate of change (replication–apoptosis), (b) insulin secretion capacity, and (c) PI/I secretion ratio. The PI/I secretion ratio is also affected by glucose. All relationships have been derived from ex vivo data (see Supplementary Information). PI/I, proinsulin/insulin.
