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Clinical trial simulation of 4βHC following 14 days of once-daily treatment with potential inducers of liver CYP3A4. (a) Mean levels of 4βHC vs. time. (b) Probability of detecting a difference relative to placebo vs. sample size on day 14. (c) Fold induction in CYP3A4 vs. the sample size to achieve 80% probability. 4βHC, 4β-hydroxycholesterol; CYP3A4, cytochrome P450 3A4.
