Table II.
Metabolites associated with self-reported current smoking of cigarettes, pipes or cigarsa
| Cases and controls | Controls | Cases | ||||||
|---|---|---|---|---|---|---|---|---|
| Metabolite | r | P-value | Metabolite | r | P-value | Metabolite | r | P-value |
| Cotinine | 0.88 | 2.64e-158 | Cotinine | 0.84 | 1.1e-60 | Cotinine | 0.91 | 3.45e-94 |
| O-Cresol sulfate | 0.72 | 3.98e-78 | O-Cresol sulfate | 0.69 | 2.63e-35 | O-Cresol sulfate | 0.74 | 1.22e-42 |
| Hydroxycotinine | 0.67 | 2.56e-60 | Hydroxycotinine | 0.66 | 1.33e-28 | Hydroxycotinine | 0.68 | 5.41e-32 |
| 4-Vinylphenol sulfate | 0.29 | 6.26e-10 | 1-Methylxanthine | 0.34 | 9.23e-07 | 4-Vinylphenol sulfate | 0.35 | 5.52e-09 |
| N-(2-furoyl)glycine | 0.25 | 2.19e-09 | 1-Methylurate | 0.32 | 1.42e-06 | N-(2-furoyl)glycine | 0.23 | 8.67e-06 |
| 1-Methylurate | 0.27 | 3.86e-09 | Trigonelline (Nʹ- methyl nicotinate) | 0.28 | 2.84e-05 | Catechol sulfate | 0.23 | 5.72e-05 |
| 1-Methylxanthine | 0.29 | 8.87e-09 | N-(2-furoyl)glycine | 0.27 | 9.37e-05 | Trigonelline (Nʹ-methyl nicotinate | 0.23 | 7.96e-05 |
| Trigonelline (Nʹ-methyl nicotinate) | 0.25 | 3.83e-08 | Paraxanthine | 0.23 | 9.81e-05 | Threonate | -0.29 | 0.000125 |
| Threonate | -0.25 | 5.05e-08 | 1,3-Dimethylurate | 0.27 | 0.000147 | 21-Hydroxypregnenolone disulfate | 0.30 | 0.000167 |
| Catechol sulfate | 0.25 | 2.03e-07 | Threonate | -0.20 | 0.000163 | Pregnenolone sulfate | 0.30 | 2e-04 |
| Quinate | 0.22 | 4.45e-06 | Catechol sulfate | 0.27 | 0.000624 | 1-Methylurate | 0.24 | 0.000369 |
| 4-Ethylphenylsulfate | 0.21 | 4.61e-06 | 1,3,7-Trimethylurate | 0.23 | 0.000719 | Quinate | 0.19 | 0.000388 |
| Scyllo-inositol | -0.19 | 2.36e-05 | Quinate | 0.26 | 0.000813 | 1-Methylxanthine | 0.25 | 0.000493 |
| Paraxanthine | 0.19 | 6.2e-05 | 4-Ethylphenylsulfate | 0.22 | 0.00101 | Andro steroid monosulfate 2 | 0.23 | 0.000967 |
| 3-Hydroxyhippurate | 0.17 | 7.07e-05 | Theophylline | 0.20 | 0.00114 | 4-Ethylphenylsulfate | 0.20 | 0.0012 |
| 21-Hydroxypregnenolone disulfate | 0.22 | 0.00014 | 1-Palmitoylglycerol | -0.23 | 0.00292 | Carnitine | 0.16 | 0.00184 |
| Piperine | -0.14 | 0.000174 | Hippurate | 0.21 | 0.00329 | Scyllo-inositol | -0.25 | 0.00197 |
| 1,3,7-Trimethylurate | 0.17 | 0.000371 | 3-Hydroxyhippurate | 0.21 | 0.00339 | 3-Carboxy-4-methyl-5- propyl-2-furanpropanoate | -0.21 | 0.00256 |
| Pregnenolone sulfate | 0.22 | 0.000645 | Caffeine | 0.17 | 0.00376 | 2-Hydroxystearate | 0.15 | 0.00272 |
| 1,3-Dimethylurate | 0.18 | 0.000824 | 4-Vinylphenol sulfate | 0.22 | 0.00585 | Dehydroisoandrosterone sulfate | 0.25 | 0.00276 |
Shaded cells reach the Bonferroni corrected P-value of 0.05/446.
aAdjusted for age, gender, race, study center and BMI.