Table I.

Gene–smoking interaction analysis using a logistic regression model

Study	Gene		Smoking		Interaction
	OR (95% CI)a	P a	OR (95% CI)a	P a	OR (95% CI)a	P a
rs1316298 smokingb
GWAS (Nanjing)	1.35 (1.12, 1.65)	2.17×10−03	4.03 (3.12, 5.22)	2.46×10−26	0.65 (0.50, 0.85)	1.28×10−03
GWAS (Beijing)	1.20 (0.92, 1.55)	1.78×10−01	4.04 (2.95, 5.52)	2.73×10−18	0.61 (0.44, 0.84)	3.09×10−03
GWAS (Total)	1.25 (1.08, 1.45)	3.53×10−03	3.81 (3.15, 4.61)	3.42×10−43	0.66 (0.55, 0.81)	4.15×10−05
Replication	1.05 (0.88, 1.27)	5.74×10−01	4.34 (3.45, 5.47)	1.53×10−35	0.64 (0.50, 0.83)	8.87×10−04
Combined	1.11 (1.00, 1.23)	5.67×10−02	3.99 (3.48, 4.58)	6.71×10−86	0.71 (0.62, 0.83)	6.73×10−06
rs4589502 smokingb
GWAS (Nanjing)	0.68 (0.53, 0.88)	3.39×10−03	2.80 (2.22, 3.55)	6.24×10−18	1.69 (1.20, 2.36)	2.33×10−03
GWAS (Beijing)	0.75 (0.54, 1.05)	9.10×10−02	2.69 (2.04, 3.54)	1.69×10−12	1.76 (1.16, 2.68)	8.37×10−03
GWAS (Total)	0.70 (0.58, 0.85)	3.95×10−04	2.66 (2.24, 3.16)	2.40×10−29	1.72 (1.34, 2.22)	2.61×10−05
Replication	0.78 (0.62, 0.98)	2.93×10−02	3.26 (2.63, 4.03)	1.17×10−27	1.39 (1.01, 1.91)	4.40×10−02
Combined	0.74 (0.64, 0.84)	1.14×10−05	3.01 (2.66, 3.42)	4.07×10−66	1.55 (1.29, 1.87)	3.84×10−06

^aAdjusted for age, gender and principal components where appropriate.

^brs1316298 (14q22.1), rs4589502 (15q22.32).