Table 3.
Multivariable-adjusted hazard ratios of all-cause, cardiovascular disease, and coronary heart disease mortality by quintile of filtration marker.
| Quintile 1* | Quintile 2* | Quintile 4* | Quintile 5* | P-trend | |||
|---|---|---|---|---|---|---|---|
| Subquintile 5a | Subquintile 5b | Subquintile 5c | |||||
| All-cause Mortality (2392 deaths/6445 participants) | |||||||
| eGFRcr | 1.33 (0.63–2.79) | 0.68 (0.32–1.43) | 0.88(0.60–1.31) | 0.83 (0.5–1.31) | 0.82 (0.53–1.26) | 1.31 (0.84–2.04) | 0.02 |
| Cystatin C | 0.76 (0.43–1.34) | 0.80 (0.48–1.33) | 1.02 (0.70–1.46) | 1.19 (0.86–1.65) | 1.10 (0.79–1.55) | 1.94 (1.43–2.62) | <0.001 |
| BTP | 1.15 (0.72–1.85) | 1.25 (0.87–1.78) | 1.06 (0.75–1.50) | 1.45 (0.98–2.14) | 1.37 (0.93–1.99) | 2.14 (1.56–2.94) | <0.001 |
| B2M | 0.90 (0.54–1.50) | 0.96 (0.61–1.52) | 1.26 (0.90–1.78) | 1.22 (0.93–1.59) | 1.79 (1.32–2.43) | 2.58 (1.96–3.41) | <0.001 |
| Cardiovascular Disease Mortality (1079 deaths/6445 participants) | |||||||
| eGFRcr | 0.61 (0.08–4.68) | 0.63 (0.14–2.78) | 1.13 (0.50–2.56) | 0.89 (0.40–1.98) | 0.97 (0.43–2.18) | 1.56 (0.71–3.43) | 0.002 |
| Cystatin C | 0.27 (0.12–0.59) | 0.83 (0.33–2.05) | 1.11 (0.67–1.82) | 1.47 (0.89–2.42) | 1.20 (0.70–2.04) | 2.10 (1.33–3.32) | <0.001 |
| BTP | 1.22 (0.53–2.81) | 0.86 (0.41–1.80) | 1.15 (0.70–1.89) | 1.32 (0.70–2.50) | 1.25 (0.71–2.17) | 2.27 (1.34–3.85) | <0.001 |
| B2M | 0.91 (0.33–2.57) | 1.27 (0.61–2.68) | 1.17 (0.70–1.96) | 1.50 (0.93–2.41) | 1.83 (1.07–3.14) | 2.59 (1.62–4.14) | <0.001 |
| Coronary Heart Disease Mortality (605 deaths/6445 participants) | |||||||
| eGFRcr | 0.53 (0.04–6.26) | 0.89 (0.15–5.25) | 1.05 (0.47–2.37) | 0.84 (0.37–1.87) | 0.85 (0.37–1.94) | 1.40 (0.69–2.84) | 0.1 |
| Cystatin C | 0.33 (0.13–0.82) | 1.13 (0.35–3.71) | 1.68 (0.90–3.15) | 2.01 (1.11–3.63) | 1.42 (0.77–2.64) | 2.61 (1.43–4.78) | 0.001 |
| BTP | 1.36 (0.47–3.88) | 1.09 (0.39–3.03) | 1.23 (0.65–2.31) | 1.08 (0.51–2.30) | 1.37 (0.66–2.84) | 2.33 (1.16–4.68) | 0.001 |
| B2M | 0.80 (0.16–3.94) | 1.86 (0.84–4.08) | 1.12 (0.71–1.76) | 1.55 (0.94–2.55) | 1.68 (0.92–3.09) | 2.15 (1.30–3.56) | 0.006 |
Note: The 95% confidence interval is shown in parentheses. Adjusted for age, sex, race, diabetes, current smoking status, systolic blood pressure, hypertension medication use, high-density lipoprotein cholesterol, natural log(triglycerides), prevalent coronary heart disease, C-reactive protein (<0.22 mg/dL, 0.22–<1.00 mg/dL, ≥1.00 mg/dL), and natural log(urinary albumin-creatinine ratio).
eGFRcr, creatinine-based estimated glomerular filtration rate, HDL, high-density lipoprotein. ACR, albumin-creatinine ratio; NHANES III, Third National Health and Nutrition Examination Survey; BTP, β-trace protein; B2M, β2-microglobulin
Quintile 3 is the reference group.