Table 4.
NRI values comparing multivariable adjusted models including a single filtration marker (eGFRcr) to additional filtration markers
| Continuous NRI | Categorical NRI** | |||||
|---|---|---|---|---|---|---|
| Event NRI | Non-event NRI | Overall NRI (95% CI) | Event NRI | Non-event NRI | Overall NRI (95% CI) | |
| Adding Cystatin C, BTP, and B2M to eGFRcr and Risk Factors | ||||||
| All participants | ||||||
| All-cause mortality | 0.226 | 0.222 | 0.448 (0.393, 0.504)‡ | 0.006 | 0.012 | 0.018 (0.005, 0.031)† |
| CVD mortality | 0.278 | 0.098 | 0.376 (0.302, 0.450)‡ | 0.005 | 0.032 | 0.037 (0.009, 0.064)† |
| CHD mortality | 0.312 | 0.112 | 0.424 (0.330, 0.518)‡ | 0.041 | 0.027 | 0.067 (0.027, 0.108)‡ |
| Participants with eGFRcr ≥60mL/min/1.73m2 | ||||||
| All-cause mortality | 0.316 | 0.211 | 0.527 (0.473, 0.580)‡ | 0.012 | 0.002 | 0.014 (0.0004, 0.028)* |
| CVD mortality | 0.392 | 0.058 | 0.449 (0.378, 0.521)‡ | 0.032 | 0.022 | 0.055 (0.027, 0.083)‡ |
| CHD mortality | 0.342 | 0.132 | 0.474 (0.381, 0.567)‡ | 0.051 | 0.018 | 0.070 (0.027, 0.113)† |
| Adding Cystatin C to eGFRcr and Risk Factors | ||||||
| All-cause mortality | 0.194 | 0.145 | 0.339 (0.281, 0.397)‡ | 0.002 | 0.008 | 0.010 (−0.001, 0.021) |
| CVD mortality | 0.321 | 0.008 | 0.329 (0.255, 0.404)‡ | 0.001 | 0.023 | 0.025 (0.002, 0.047)* |
| CHD mortality | 0.426 | 0.019 | 0.446 (0.357, 0.535)‡ | 0.046 | 0.010 | 0.056 (0.017, 0.095)† |
| Adding BTP and B2M to Cystatin C and eGFRcr and Risk Factors | ||||||
| All-cause mortality | 0.187 | −0.0137 | 0.174 (0.120, 0.227)‡ | 0.004 | 0.004 | 0.008 (−0.004, 0.019) |
| CVD mortality | 0.244 | 0.074 | 0.318 (0.243, 0.393)‡ | 0.002 | 0.010 | 0.012 (−0.010,0.033) |
| CHD mortality | 0.130 | 0.142 | 0.273 (0.171, 0.374)‡ | −0.002 | 0.017 | 0.015 (−0.016, 0.046) |
Note: Adjusted for age, sex, race, diabetes, current smoking status, systolic blood pressure, hypertension medication use, high-density lipoprotein-cholesterol, natural log(triglycerides), prevalent CHD, C-reactive protein (<0.22 mg/dL, 0.22–<1.00 mg/dL, ≥1.00 mg/dL), and natural log(urinary albumin-creatinine ratio).
*
p≤0.05,
†
p≤0.01,
‡
p≤0.001
**
10-year risk categories: <0.05, 0.05–0.20, >0.20.
NRI, net reclassification improvement; eGFRcr, creatinine-based estimated glomerular filtration rate; BTP, β-trace protein; B2M, β2-microglobulin; CVD, cardiovascular disease; CHD, coronary heart disease; CI, confidence interval