Deletion of PI3K catalytic subunits, p110α and p110β, in GALP neurons does not affect body weight gain or metabolic parameters in male and female mice. Postweaning body weight gain in GALP-p110α/β cKO males (A) and females (B) and WT littermates on normal chow (P > 0.05, n =13–15). (C) Food intake (D) heat production, (E) volume of oxygen consumed (VO2), (F) respiratory exchange ratio (RER), and (G) ambulatory movement of 5-month old chow-fed GALP-p110α/β cKO male (n = 9) and female (n = 8) mice, and their littermate controls (6–11) were measured by a combined Oxymax indirect calorimetric system over a 24-hr time period. Values are mean ± SEM.