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. Author manuscript; available in PMC: 2015 Aug 1.
Published in final edited form as: Biomaterials. 2014 Jun 8;35(26):7647–7653. doi: 10.1016/j.biomaterials.2014.05.045

Fig. 6.

Fig. 6

TUNEL assay and detection of CDDP-DNA adduct in an A375M tumor model. The mice were sacrificed 24 h after receiving a single IV injection of LPI NPs at a dose of 1.0 mg/kg Pt. The apoptotic tumor cells were detected by the TUNEL assay (A, green); the formation of CDDP-DNA adducts in tumor cells were detected by CDDP-DNA adduct antibody (B, green). Cell nuclei were stained with DAPI. The number represents the percentage of apoptotic cells (A) or CDDP-DNA adduct positive cells (B).