Table 1.
PKPD indices for major classes of antibacterial agents.
| Pharmacodynamics | Class of antibacterial | Specific drug (where applicable) | PD parameter | PD target of therapy |
|---|---|---|---|---|
| Time-dependent | Beta-lactams | – | %T>MIC [9] | Max %T in the dosing interval > MIC |
| Macrolides | Conventional macrolides | %T>MIC [192] | Max %T in the dosing interval > MIC | |
| Azithromycin | AUC/MIC [9] | Optimal daily amount | ||
| Glycopeptides | – | AUC/MIC [57] | Optimal daily amount | |
| Tetracyclines | – | AUC/MIC [191] | Optimal daily amount | |
| Oxazolidinones | Conventional oxazolidinones | %T>MIC [192] | Max %T in the dosing interval > MIC | |
| Linezolid | AUC/MIC [191] | Optimal daily amount | ||
| Concentration-dependent | Aminoglycosides | – | Cmax/MIC or AUC/MIC [10] | Max peak concentration or optimal daily amount |
| (Fluoro)quinolones | – | Cmax/MIC or AUC/MIC [66] | Max peak concentration or optimal daily amount | |
| Metronidazole | – | Cmax/MIC or AUC/MIC [192] | Max peak concentration or optimal daily amount |