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. Author manuscript; available in PMC: 2014 Dec 1.
Published in final edited form as: Eur J Immunol. 2013 Sep 6;43(12):3279–3290. doi: 10.1002/eji.201343727

Figure 8. BCG vaccinated mice boosted with exosomes from CFP-treated macrophages were protected against a low-dose aerosolized M. tuberculosis infection.

Figure 8

Six weeks after the final exosome vaccination mice were infected with virulent M. tuberculosis H37Rv by aerosol challenge and 6 weeks later the mycobacterial burden in the lungs (A) and spleens (B) was determined by plating the tissue homogenates on 7H10 agar plates. Results are expressed as the means ± standard error for 4 mice per group and the data shown is the representative of two independent experiments. *, p < 0.05 compared to PBS control; **, P < 0.05 compared to BCG primed/BCG boost vaccinated mice; as determined by Student paired t-test.