Table 1.
Characteristics of Study Subjects
| Gender | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Participant category (n) | Median age [years (IQR)a] | %Male (no.) | %Female (no.) | %MTFb(no.) | %Intersex (no.) | Median HIV viral loadc[log10 copies/ml (IQR)] | Median CD4+ T cell countd[cells/mm3 (IQR)] | Median CD4+ T cell nadir counte[cells/mm3 (IQR)] | Median CD8+ T cell activationf[%CD38+ HLA−DR+ (IQR)] |
| HIV+ noncontrollers (n=20) (NC) | 44 (25, 70) | 80 (16) | 5 (1) | 10 (2) | 5 (1) | 4.51 (1.01, 5.69) | 518.5 (368, 1,088) | 371.5 (100, 565) | 33.65 (11.1, 64.7) |
| HIV+ elite controllers (n=20) (EC) | 51 (37, 72) | 80 (16) | 15 (3) | 5 (1) | 0 (0) | 1.6 (0, 1.87) | 780.5 (518, 1,850) | 624.5 (255, 1,100) | 10.45 (3.88, 40.30) |
| HIV+ ARV suppressed (n=20) (AS) | 50 (39, 66) | 75 (15) | 15 (3) | 10 (2) | 0 (0) | 1.6 (0.26, 1.87) | 719.5 (433, 1,693) | 115.5 (8, 423) | 8.71 (2.67, 32) |
| HIV negative (n=19) (Neg) | 51 (49, 53) | 95 (18) | 5 (1) | 0 (0) | 0 (0) | N/A | N/A | N/A | N/A |
a
IQR, interquartile range.
b
MTF, male to female.
c
HIV viral load (NC vs. EC, p<0.0001), (NC vs. AS, p<0.0001).
d
CD4+ T cell count (NC vs. EC, p<0.0001), (NC vs. AS, p=0.002).
e
CD4+ T cell nadir count (NC vs. EC, p=0.001), (NC vs. AS, p<0.0001), (EC vs. AS, p=0.0001).
f
CD8+ T cell activation (NC vs. EC, p<0.001), (NC vs. AS, p<0.0001).