Table 2.

Unadjusted and Adjusted Hazard Ratios (HR) of Radiographic OA (rOA) and Chronic Symptoms Outcomes, by Joint Site.

	LLI* Present?	# of Joints at Risk	# of Joints with Outcome	Unadjusted HR (95% CI†)	Adjusted‡ HR (95% CI†)
Incident Knee rOA	Yes	122	20	1.20 (0.72–2.00)	1.08 (0.66–1.76)
	No	2612	398
Progressive Knee rOA 1§	Yes	85	37	1.70 (1.15–2.51)	1.22 (0.82–1.80)
	No	1197	405
Progressive Knee rOA 2**	Yes	47	24	2.84 (1.72–4.69)	1.83 (1.10–3.05)
	No	328	148
Incident Knee Symptoms	Yes	98	18	0.68 (0.42–1.09)	0.83 (0.47–1.47) ††
	No	1998	463
Progressive Knee Symptoms	Yes	50	18	1.19 (0.66–2.15)	1.13 (0.53–2.39) ††
	No	510	195
Incident Hip rOA	Yes	119	12	1.27 (0.72–2.23)	1.17 (0.66–2.07)
	No	1898	187
Progressive Hip rOA 1§	Yes	130	16	1.63 (0.96–2.76)	1.32 (0.78–2.22)
	No	2305	189
Progressive Hip rOA 2**	Yes	33	4	2.11 (0.60–7.37)	1.34 (0.37–4.83)
	No	629	36
Incident Hip Symptoms	Yes	142	69	1.20 (0.90–1.60)	1.21 (0.82–1.77) ††
	No	2572	968
Progressive Hip Symptoms	Yes	22	7	1.15 (0.46–2.85)	0.95 (0.23–3.94) ††
	No	295	117

^*LLI = limb length inequality

^†CI= confidence interval

^‡Adjusted for baseline age, baseline BMI, gender, race, and joint problems (i.e., injury, surgery, or fracture).

^§An increase of at least 1 K-L grade from T0 assessment to T1 assessment among individuals with at least K-L grade of 1 at T0.

^**An increase of at least 1 K-L grade from T0 assessment to T1 assessment among individuals with at least K-L grade of 2 at T0.

^††Adjusted for baseline age, baseline BMI, gender, race, joint problems in same joint, and OA (presence of K-L grade of at least 2) in same joint.