. 2014 Apr 22;14:276. doi: 10.1186/1471-2407-14-276

Table 5.

The statistical difference between E2F lower, moderate and higher and clinicopathological variables

Variables		E2F1 expression			Spearman		χ2 test
		−/+	++	+++	R	P	χ2	P
Age	<55	7	11	19	0.103	0.334	1.069	0.586
Age	≥55	8	12	33	0.103	0.334	1.069	0.586
Gender	Male	9	20	39	0.038	0.725	3.193	0.166
Gender	Female	6	3	13	0.038	0.725	3.193	0.166
Smoking	Non-smoker	4	3	14	0.068	0.518	1.829	0.411
Smoking	Smoker	11	20	38	0.068	0.518	1.829	0.411
Tumor size	<4 cm	9	12	35	0.105	0.325	1.592	0.451
Tumor size	≥4 cm	6	11	17	0.105	0.325	1.592	0.451
Clinical stage	LD*	13	10	7	0.552	< 0.01	29.506	<0.01
Clinical stage	ED*	2	13	45	0.552	< 0.01	29.506	<0.01

−/+ represents E2F1 weak expression, ++ represents E2F1 moderate expression, +++ represents E2F1 higher expression, LD* represents limited disease and ED* represents extensive disease.