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Schematic illustration of the mechanisms of plek2 in the early and late stage of terminal erythropoiesis. (A) In the early stage of terminal erythropoiesis, plek2 is required to regulate actin cytoskeleton integrity and prevent apoptosis by inhibiting cofilin’s mitochondrial entry. (B) In the late stage, ROS is decreased due to mitochondria autophagy. Phospho-cofilin is increased. Plek2 mainly functions in enucleation through the regulation of actin cytoskeleton.
