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. 2012 Jan 23;33(3):393–400. doi: 10.1038/aps.2011.179

Figure 2.

Figure 2

Aldosterone infusion with or without additional 1% sodium chloride intake induce left ventricular (LV) hypertrophy by echocardiographic analysis and ultrastructural remodeling visible by TEM in rats. (A) aldosterone infusion with or without additional 1% sodium chloride intake induce LV hypertrophy and diastolic dysfunction. LVAW, LV anterior wall thickness at end diastole; LVPW, LV posterior wall thickness at end diastole; E/A, the ratio of mitral inflow measurements of early to late filling velocities; CON, control rats; ALD, excess aldosterone alone-infused rats; HS-ALD, 1% NaCl in conjunction with aldosterone in rats. Mean±SD. n=8. bP<0.05 vs CON; eP<0.05 vs ALD. (B) Representative image from CON demonstrating a line of sarcolemmal mitochondria just beneath the sarcomeres (the distance between two Z lines) of the myocardium. Representative remodeled mitochondria in ALD rats. This image represents marked increase of swollen and denatured mitochondria. The myocardial ultrastructure was disappeared in some spaces and mitochondria of myocardium were dissolved in HS-ALD group. Original magnifications: ×10 000.