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The bootstrap tree of the prototypical members from human class C GPCRs. The sequence of the VFT were aligned using the default parameters and the homologous bacterial PBPs were used as an outgroup to root the trees. Class C GPCRs form obligatory dimers. Homodimers (mGluR and CaSR) linked by a disulfide bond between their VFTs, while heterodimers (GABABR and T1R) are not covalently linked.
