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Percentage of the orphan GPCRs in GPCR superfamily. GPCRs constitute a large transmembrane family of more than 800 members. Among them, 6% are utilized as drug target in clinical applications, and 30% are natural ligand receptors. However, 49% are olfactory receptors (most of them are orphan GPCRs), and 15% are orphan GPCRs. (Data were summarized from a review paper122)
