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. 2012 Feb 27;33(3):363–371. doi: 10.1038/aps.2011.210

Figure 2.

Figure 2

LGR subfamily GPCRs. The Type A LGRs includes the follicle-stimulating hormone receptor (FSHR), the luteinizing hormone receptor (LHR) and the thyroid-stimulating hormone receptor (TSHR). The Type B LGR comprises three members, Gpr48/LGR4, LGR5, and LGR6 which remain orphan GPCRs at the present time. By contrast, Type C LGRs have only two members, LGR7 and LGR8 which have been demonstrated to be the relaxin family receptors. Type A contains 9 LRRs in the ectodomain, whereas Type B contains 17 LRRs. By contrast, Type C has an N-terminal LDL receptor-like cysteine-rich domain not found in other LGRs. 7TM, seven-transmembrane; LDL, low-density lipoprotein; LRR, leucine-rich repeat; LGR, leucine-rich repeat-containing G-protein-coupled receptor; FSHR, follicle-stimulating hormone receptor; LHR, luteinizing hormone receptor; TSHR, thyroid-stimulating hormone receptor.