Table 1.
Schedule of assessments
| Assessment | Baseline | Follow-up |
|---|---|---|
|
Demographics |
|
|
| Worksituation |
|
X |
| Education |
|
X |
| Marital status |
|
X |
| Social/living status |
|
X |
| Oncologic diagnose |
X |
X |
|
Radiotherapy |
|
|
| Dosis Total (Gy) |
X |
X |
| Dosis per fraction (Gy) |
X |
X |
| Number of fractions |
X |
X |
| Bilateral/unilateral |
X |
X |
| Dose on common carotid artery |
X |
X |
| Dose on internal carotid artery |
X |
X |
|
Medical history |
|
|
| Cerebrovascular events |
X |
X |
| Cerebrovascular risk factors |
X |
X |
| Cardiovascular events |
|
X |
| Hypertension |
X |
X |
| Hypercholostrolemia |
|
X |
| Smoking |
X |
X |
| Diabetes |
|
X |
| Family history of cerebrovascular disease |
|
X |
| Obesity |
|
X |
| Migraine |
|
X |
|
Medication use |
|
|
| Aspirin |
|
X |
| Oral anticoagulance |
|
X |
| Antihypertensive medication |
|
X |
| Statin |
|
X |
| Anti-diabetic medication |
|
X |
|
Physical examination |
|
|
| Length and weight |
|
X |
| Waist circumference |
|
X |
| Blood pressure |
X |
X |
| BMI |
|
X |
|
Neurological examination |
|
|
| Cranial nerves |
|
X |
| Muscle strength |
|
X |
| Coordination |
|
X |
|
Mobility |
|
|
| Time up and Go/Tinetti |
|
X |
|
ECG |
|
|
| Paroxysmal atrial fibrillation |
|
X |
| Left ventricle hypertrophia |
|
X |
| Ischemia |
|
X |
|
Fasting laboratory investigation |
|
|
| Glucose |
|
X |
| Total cholesterol |
|
X |
|
Ultrasonography |
|
|
| IMT |
X |
X |
| Elastography |
|
X |
|
Neuropsychological Examination |
|
|
|
Global cognitive functioning |
|
|
| Minimal Mental State Examination (MMSE) |
|
X |
| Frontal Assessment Battery (FAB) |
|
X |
| 1. Episodic Memory |
|
|
| Rey Auditory Verbal Learning Test (RAVLT) |
|
X |
| 2. Working memory |
|
|
| Paper and Pencil Memory Scanning Tasks |
|
X |
| Digit Span test |
|
X |
| 3. Executive functioning |
|
|
| Stroop Color-Word Task |
|
X |
| Trail Making Test (TMT) |
|
X |
| Brixton Spatial Anticipation Test |
|
X |
| 4. Attention |
|
|
| Verbal Series Attention Test(VSAT) |
|
X |
| 5. Fluency Language |
|
|
| Letter fluency |
|
X |
| Animal fluency |
|
X |
| 6. Speed information processing |
|
|
| TMT A |
|
X |
| Stroop test (mean score Parts I and II) |
|
X |
| Letter Digity Substitution Task |
|
X |
|
Questionnaires |
|
|
|
Depressive symptoms |
|
|
| Structured questionnaire depressive symptoms |
|
X |
| Mini International Neuropsychiatric Interview (MINI) |
|
X |
| Hospital Anxiety and Depression Scale (HADS) |
|
X |
| Center of Epidemiological Studies Depression scale |
|
X |
|
Fatigue |
|
|
| CIS 20 R |
|
X |
|
Health related Quality of Life |
|
|
| Short form36 |
|
X |
|
Others |
|
|
| Structured questionnaire about sleep disorders |
|
X |
| Subjective memory complaints |
|
X |
|
MRI |
|
|
| Brain (T1, T2, FLAIR) |
|
X |
| Carotid arteries (TOF, PCA, T1, T2, PD) | X |