Table 1.
Pharmacokinetic parameters of sildenafil and N -desmethyl sildenafil a
|
Case |
Sildenafil AUC
0–6h
((ng/ml)×h) |
N
-desmethyl sildenafil AUC
0–6h
((ng/ml)×h) |
MR |
Absolute bioavailability (%) |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| IV | Ent | SL | IV | Ent | SL | IV | Ent | SL | IV | Ent | SL | |
| 1 |
– |
5.76 |
26.6 |
– |
31.8 |
42.8 |
– |
0.18 |
0.6 |
– |
– |
– |
| 2 | 919 | 25.5 | 106 | 70.4 | 74.7 | 37.2 | 12.7 | 0.33 | 2.78 | 100 | 2.78 | 11.6 |
aAUC0–6h, Estimated area under the concentration–time curve in a 6-hour dosing interval, normalized to dose; IV, Intravenous; Enteral; SL, Sublingual; MR, Metabolic sildenafil/N-desmethyl sildenafil ratio.