Table 3.
Clinical and physiological findings of patients with or without HHH
| HHH (n = 29) | No HHH (n = 41) | P a value | |
|---|---|---|---|
| Organomegaly | |||
| Hepatomegaly | 16 (55.2 %) | 15 (36.6 %) | |
| Splenomegaly | 16 (55.2 %) | 12 (29.3 %) | |
| Laboratory data | |||
| WBC max (x103/μl) | 18.5 ± 13.6 | 17.4 ± 8.9 | |
| WBC min (x103/μl) | 4.3 ± 7.4 | 5.7 ± 3.3 | <0.05 |
| Hb (g/dl) | 7.2 ± 2.4 | 8.1 ± 2.5 | |
| Plt (x104/μl) | 5.7 ± 10.8 | 11.6 ± 9.7 | <0.05 |
| AST (IU/l) | 147 ± 170 | 766 ± 2,807 | |
| Triglyceride (mg/dl) | 239 ± 244 | 147 ± 89 | |
| IL-12 (pg/ml) | 19.0 ± 92.2 | 13.4 ± 64.4 | |
| IFN-γ (pg/ml) | 361.2 ± 1,854.2 | 17.3 ± 50.0 | |
| TNF-α (pg/ml) | 8.4 ± 26.7 | 1.4 ± 1.2 | |
| IL-10 (pg/ml) | 172.8 ± 407.8 | 78.9 ± 372.5 | |
| IL-6 (pg/ml) | 20,662.2 ± 28,447.0 | 4,262.5 ± 11,769.6 | <0.05 |
| IL-1β (pg/ml) | 749.8 ± 2,383.8 | 95.5 ± 561.1 | <0.05 |
| IL-8 (pg/ml) | 24,439.7 ± 42,733.5 | 577.0 ± 816.1 | <10−4 |
| Macrophages in BM cells (%) | 25.2 ± 20.0 | 12.1 ± 4.0 | <0.001 |
HHH histiocytic hyperplasia with hemophagocytosis, WBC max maximum number of WBC, WBC min minimum number of WBC
aAdjusted using the Holm method for multiple testing