Table 5.
Features of patients with hypo-HHH or other HHH
| Hypo-HHH (n = 8) | Other HHH (n = 21) | P a value | |
|---|---|---|---|
| Hematological diseases | 7 (87.5 %) | 7 (33.3 %) | |
| BM macrophages (≥25 %) | 7 (87.5 %) | 1 (4.8 %) | <0.001 |
| WBC max (×103/μl) | 17.9 ± 16.6 | 18.7 ± 12.8 | |
| WBC min (×103/μl) | 0.6 ± 0.7 | 5.8 ± 8.2 | <0.05 |
| Hb (g/dl) | 6.1 ± 1.2 | 7.6 ± 2.6 | |
| Plt (×104/μl) | 1.1 ± 1.1 | 7.5 ± 12.4 | |
| Triglyceride (mg/dl) | 408 ± 315 | 155 ± 150 | |
| IL-12 (pg/ml) | 1.8 ± 1.4 | 25.6 ± 108.3 | |
| IFN-γ (pg/ml) | 33.4 ± 65.8 | 486.0 ± 2,780.0 | |
| TNF-α (pg/ml) | 20.6 ± 3.8 | 49.5 ± 7.6 | |
| IL-10 (pg/ml) | 472.9 ± 708.8 | 58.5 ± 85.3 | |
| IL-6 (pg/ml) | 29,865.0 ± 33,572.3 | 17,156.4 ± 26,299.4 | |
| IL-1β (pg/ml) | 2,005.6 ± 4061.3 | 271.6 ± 1,145.6 | |
| IL-8 (pg/ml) | 57,155.8 ± 62,993.6 | 11,976.4 ± 24,010.6 | <0.05 |
HHH histiocytic hyperplasia with hemophagocytosis, WBC max maximum number of WBC, WBC min minimum number of WBC
aAdjusted using the Holm method for multiple testing