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. 2014 May 6;10:17. doi: 10.1186/1744-9081-10-17

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Copyright © 2014 dela Peña et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Reinforcing effects of repeated methylphenidate treatment in spontaneously hypertensive rats (SHRs). (A) Methylphenidate (MPH) CPP in cohort 1 (saline-pretreated SHR conditioned with methylphenidate, SAL + MPH) and cohort 2 (methylphenidate-pretreated SHR conditioned methylphenidate, MPH + MPH) rats. During the conditioning phase of the CPP test, the rats in both cohorts were administered 5 mg/kg dose of MPH. The control group received saline only. Each bar represents the mean ± S.E.M. of the difference in the time spent in the drug- or saline- (for control group) paired side during the post- and preconditioning phases. ***P < 0.001, significantly different from the saline-treated groups. n = 10-12 rats per group. (B) MPH self-administration shown by saline-treated (SAL + MPH) and methylphenidate-pretreated (MPH + MPH) SHR. The mean number of methylphenidate infusions obtained by rats over the 6 days of methylphenidate self-administration is shown. Each symbol represents the mean ± S.E.M. n = 7-9 animals per group.