Table 1.
Exp. | Dose | Body Weight (g)
|
BACs (mg/dL)
|
|||||
---|---|---|---|---|---|---|---|---|
PD7 (males) | PD7 (females) | PD9 (males) | PD9 (females) | PD31 (males) | PD31 (females) | PD7 | ||
1 | SI | 14.05 ± 0.58 | 15.33 ± 0.50 | 18.62 ± 0.79 | 19.59 ± 0.65 | 100.46 ± 3.70 | 96.93 ± 2.30 | n/a |
2.75g | 14.89 ± 0.45 | 14.69 ± 0.33 | 19.46 ± 0.60 | 19.26 ± 0.39 | 110.00 ± 2.22 | 96.27 ± 2.34 | 210.61 ± 7.35 | |
4.00g | 15.87 ± 0.46 | 14.57 ± 0.59 | 18.76 ± 0.58 | 17.51 ± 0.64 | 106.75 ± 3.29 | 94.75 ± 2.36 | 322.00 ± 7.03 | |
5.25g | 15.23 ± 0.43 | 15.17± 0.38 | 15.56 ± 0.52* | 16.52 ± 0.68* | 99.23 ± 3.45 | 95.50 ± 1.87 | 414.00 ± 13.41 | |
2 | SI | 15.99 ± 0.29 | 15.15 ± 0.31 | 21.06 ± 0.41 | 19.58 ± 0.46 | 106.21 ± 1.56 | 96.82 ± 1.10 | n/a |
EtOH | 15.78 ± 0.42 | 15.09 ± 0.36 | 15.60± 0.50* | 15.59 ± 0.37* | 98.25 ± 2.37* | 89.80 ± 1.74* | 426.81 ± 6.56 |
Average body weights (± SE) are shown from 4 Treatment Conditions in Experiment 1 (SI, sham intubated; 2.75; 4.00; and 5.25 g) taken from the first and last day of the dosing period (PND7 and PND9, respectively). For Experiment 2, body weights were recorded for the 2 Treatment Conditions (SI, sham intubated; and Group EtOH). Significant differences in body weight compared with SI are noted with an *. Body weights taken at the beginning of preexposure (PND31) are also summarized for each experiment (Exp 1; n=94/96 rats; Exp 2; n=65). In all experiments, PND31 weights for females were significantly lower than males (Exp 1; n=47 males, 47 females; Exp 2; n=33 males, 32 females) BACs were taken from blood samples collected on the first day of dosing (PND7) from all ethanol-exposed groups (reported in mg/dl). (Exp 1 n=33 males, 35 females; Exp 2 n=16 males, 15 females) BAC - blood alcohol concentration.