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. Author manuscript; available in PMC: 2015 Jul 1.
Published in final edited form as: Hippocampus. 2014 Mar 28;24(7):808–818. doi: 10.1002/hipo.22272

FIGURE 2.

FIGURE 2

URB597 inhibits LTP in hippocampal slices from adult CB1R WT mice but not KO mice. (A) A schematic diagram showing the positions of the stimulating and recording electrodes in the CA1 region of the hippocampus. (B) A summary graph showing the field input/output relationships in WT slices. (C) Time course of the averaged fEPSP slopes in WT slices with and without URB597 (solid line 1 μM for 30 min). (D) A summary graph showing the field input/output relationships for KO slices with and without URB597. (E) Time course of the averaged fEPSP slopes in KO slices. Arrows denote the time of tetanic stimulation. (F) A combined plot of the averages of the fEPSP slopes for WT and KO slices with and without URB597. Each point is presented as the mean ± SEM (n= 5 mice/group; 10 slices/group) (Two-way ANOVA with Bonferroni’s post hoc tests), ***p < 0.001 vs. CB1WT + Vehicle; # p < 0.05 vs. CB1WT + Vehicle; $ p < 0.05 vs. CB1WT + URB597.