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Peptide assembly by SPPS, exemplarily shown for a tetrapeptide. First, the C-terminal amino acid is coupled to the linker. The peptide chain will be elongated by repeating a cycle of 1) deprotection of NPG, 2) activation of the carboxy group and 3) coupling. At the end of the synthesis, the protecting groups will be cleaved and the desired peptide obtained. NPG: Nα-protecting group, X: activator, SPG: side-chain protecting group, Aa: amino acid.
