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MTAP. (A): MTAP metabolic pathway in normal cells. (B): MTAP-deficient cells are unable to salvage adenine and rely on de novo biosynthesis of purines.
Abbreviations: 5-FU, 5-fluorouracil; 6-TG, 6-thioguanine; MTA, methylthioadenosine; MTAP, methylthioadenosine phosphorylase; MTR-1-P, methylthioribose-1-phosphate; PRPP, 5′-phosphoribosyl-1-pyrophosphate.
