Table 2.
Combination Analysis of TNF-α -1031T>C, -308G>A, and -238G>A Polymorphisms in Korean Patients With Recurrent Spontaneous Abortion and in Controls.
| Characteristics | Controls, n = 236 | Patients With RSA, n = 357 | AOR (95% CI) | P a |
|---|---|---|---|---|
| TNF-α -1031T>C/-308G>A | ||||
| TT/GG | 171 (72.5) | 197 (55.2) | 1.000 | |
| TT/GA+AA | 20 (8.4) | 33 (9.2) | 1.425 (0.786-2.583) | .243 |
| TC+CC/GG | 42 (17.8) | 122 (34.2) | 2.467 (1.639-3.714) | <.001 |
| TC+CC/GA+AA | 3 (1.3) | 5 (1.4) | 1.420 (0.334-6.044) | .635 |
| TNF-α -1031T>C/-238G>A | ||||
| TT/GG | 188 (79.7) | 228 (63.9) | 1.000 | |
| TT/GA+AA | 3 (1.3) | 2 (0.5) | 0.526 (0.087-3.187) | .485 |
| TC+CC/GG | 40 (16.9) | 102 (28.6) | 2.037 (1.343-3.090) | .001 |
| TC+CC/GA+AA | 5 (2.1) | 25 (7.0) | 4.054 (1.520-10.812) | .005 |
| TNF-α -308G>A/-238G>A | ||||
| GG/GG | 205 (86.9) | 292 (81.8) | 1.000 | |
| GG/GA+AA | 8 (3.4) | 27 (7.6) | 2.366 (1.053-5.317) | .037 |
| GA+AA/GG | 23 (9.7) | 38 (10.6) | 1.169 (0.675-2.023) | .577 |
Abbreviations: AOR, adjusted odds ratio; CI, confidence interval; RSA, recurrent spontaneous abortion; TNF-α, tumor necrosis factor-α.
a Adjusted by age of all participants.