Table 3.
Haplotype Frequencies of TNF-α -1031T>C, -308G>A, and -238G>A Polymorphisms in Korean Patients With Recurrent Spontaneous Abortion and in Controls.
| Characteristics | Controls, 2n = 472 | Patients With RSA, 2n = 714 | OR (95% CI) | P a |
|---|---|---|---|---|
| TNF-α -1031T>C/-308G>A/-238G>A | ||||
| T-G-G | 400 (84.7) | 532 (74.5) | 1.000 | |
| T-G-A | 4 (0.8) | 2 (0.3) | 0.376 (0.068-2.064) | .411b |
| T-A-G | 24 (5.2) | 40 (5.6) | 1.253 (0.743-2.113) | .396 |
| C-G-G | 40 (8.5) | 114 (16.0) | 2.143 (1.461-3.143) | <.001 |
| C-G-A | 4 (0.8) | 26 (3.6) | 4.887 (1.692-14.119) | .001 |
| TNF-α -1031T>C/-308G>A | ||||
| T-G | 402 (85.2) | 536 (75.1) | 1.000 | |
| T-A | 24 (5.2) | 40 (5.6) | 1.250 (0.741-2.108) | .402 |
| C-G | 46 (9.6) | 138 (19.3) | 2.250 (1.573-3.218) | <.001 |
| TNF-α -1031T>C/-238G>A | ||||
| T-G | 424 (89.9) | 572 (80.1) | 1.000 | |
| T-A | 4 (0.8) | 2 (0.3) | 0.371 (0.068-2.034) | .411b |
| C-G | 40 (8.5) | 114 (16.0) | 2.113 (1.442-3.094) | <.001 |
| C-A | 4 (0.8) | 26 (3.6) | 4.818 (1.669-13.913) | .001 |
| TNF-α -308G>A/-238G>A | ||||
| G-G | 440 (93.2) | 646 (90.5) | 1.000 | |
| G-A | 8 (1.6) | 28 (3.9) | 2.384 (1.076-5.280) | .028 |
| A-G | 24 (5.2) | 40 (5.6) | 1.135 (0.675-1.910) | .633 |
Abbreviations: OR, odds ratio; CI, confidence interval; RSA, recurrent spontaneous abortion; TNF-α, tumor necrosis factor-α.
a Chi-square test.
b Fisher exact test.