Table 2.
Ordinal logistic regression analysis for the association of renal indicators and cerebral microbleeds
| |
|
|
|
|
Model1
†
|
|
|
Model2
‡
|
|
|
|
|
|
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Variables | N | Unadjusted OR | 95% CI | P | Adjusted OR | 95% CI | p | Adjusted OR | 95% CI | p | Adjusted OR | 95% CI | p |
| Age |
|
1.02 |
1.01-1.04 |
<0.01 |
1.02 |
1.02-1.04 |
<0.01 |
1.01 |
1.00-1.03 |
0.07 |
1.02 |
1.01-1.04 |
0.02 |
| Male |
|
1.08 |
0.65-1.31 |
0.66 |
1.36 |
0.73-1.36 |
0.76 |
1.36 |
0.91-2.03 |
0.13 |
1.31 |
0.87-1.31 |
0.20 |
| Hypertension |
|
1.74 |
1.24-2.44 |
<0.01 |
1.43 |
1.05-2.18 |
0.03 |
1.51 |
1.05-2.19 |
0.03 |
1.53 |
1.06-2.23 |
0.02 |
| Diabetes |
|
1.19 |
0.82-1.72 |
0.36 |
0.85 |
0.57-1.28 |
0.45 |
1.23 |
0.74-1.68 |
0.59 |
1.18 |
0.78-1.78 |
0.44 |
| Dyslipidemia |
|
1.35 |
0.51-1.08 |
0.12 |
0.68 |
0.45-1.02 |
0.06 |
1.22 |
1.00-2.19 |
0.05 |
1.49 |
1.00-2.22 |
0.05 |
| Heart disease |
|
1.15 |
0.70-1.70 |
0.48 |
1.05 |
0.66-1.66 |
0.82 |
1.05 |
0.70-1.60 |
0.80 |
1.00 |
0.65-1.52 |
1.00 |
| Smoking |
|
1.62 |
1.12-2.34 |
0.01 |
1.35 |
0.86-2.13 |
0.05 |
1.91 |
1.25-2.92 |
<0.01 |
1.52 |
1.01-2.28 |
<0.01 |
| Anticoagulant or thrombotics |
|
2.26 |
1.53-2,26 |
<0.01 |
1.72 |
1.08-2.72 |
0.02 |
1.51 |
1.00-2.29 |
0.05 |
1.48 |
0.98-2.25 |
0.07 |
| Total cholesterol |
|
1.07 |
0.91-1.26 |
0.42 |
1.01 |
0.81-1.01 |
0.43 |
1.01 |
0.85-1.21 |
0.89 |
1.03 |
0.87-1.23 |
0.72 |
| WML* |
|
|
|
|
|
|
|
|
|
|
|
|
|
| Confluent |
|
6.24 |
3.96-9.83 |
<0.01 |
4.08 |
2.37-7.02 |
<0.01 |
4.82 |
2.98-7.80 |
<0.01 |
4.56 |
2.80-7.41 |
<0.01 |
| Early confluent |
|
3.92 |
2.47-6.22 |
<0.01 |
2.66 |
1.60-4.41 |
<0.01 |
2.72 |
1.74-4.25 |
<0.01 |
2.62 |
1.67-4.12 |
<0.01 |
| Puctate |
|
1.82 |
1.06-3.14 |
0.03 |
1.31 |
0.72-2.39 |
0.38 |
1.57 |
0.91-2.70 |
0.11 |
1.45 |
0.83-2.51 |
0.19 |
| Normal |
|
ref |
|
|
ref |
|
|
|
|
|
ref |
|
|
|
p for trend |
|
|
|
<0.01 |
|
|
<0.01 |
|
|
|
|
|
<0.01 |
| Quartiles of cystatin C |
|
|
|
|
|
|
|
|
|
|
|
|
|
| Q4(≥66.7) |
168 |
2.19 |
1.40-3.40 |
<0.01 |
1.90 |
1.07-3.37 |
0.02 |
|
|
|
1.88 |
1.05-3.38 |
0.03 |
| Q3(54.7-66.7) |
173 |
1.57 |
0.92-2.46 |
0.10 |
1.31 |
0.45-1.28 |
0.35 |
|
|
|
1.24 |
0.74-2.08 |
0.42 |
| Q2(47.2-54.7) |
162 |
0.98 |
0.61-1.58 |
0.16 |
1.54 |
0.85-2.80 |
0.16 |
|
|
|
0.83 |
0.49-1.41 |
0.49 |
| Q1(≤47.2), ref |
180 |
|
|
|
|
|
|
|
|
|
|
|
|
| p for trend |
|
|
|
<0.01 |
|
|
<0.01 |
|
|
|
|
|
<0.01 |
| Quartiles of eGFR* |
|
|
|
|
|
|
|
|
|
|
|
|
|
| Q4(≤66.1) |
171 |
2.26 |
1.42-3.62 |
<0.01 |
|
|
|
1.82 |
0.38-4.00 |
0.72 |
1.28 |
0.38-4.36 |
0.70 |
| Q3(66.1-78.8) |
175 |
1.23 |
0.50-1.33 |
0.41 |
|
|
|
1.44 |
0.95-3.99 |
0.67 |
0.78 |
0.35-1.70 |
0.93 |
| Q2(78.8-94.7) |
164 |
1.18 |
0.50-1.40 |
0.51 |
|
|
|
1.33 |
0.70-2.11 |
0.50 |
1.11 |
0.61-2.03 |
1.11 |
| Q1(≥94.7),ref |
173 |
|
|
|
|
|
|
|
|
|
|
|
|
| p for trend | <0.01 | <0.01 | 0.51 |
*WML; white matter lesions, eGFR; estimated glomerular filtration rate.
†Model 1: quartiles of estimated GFR and cystatin C were analyzed separately in the individual ordinal logistic regression model.
‡Model 2: quartiles of estimated GFR and cystatin C were analyzed together in the same logistic regression model.
Model 1 and model 2 were adjusted for covariates; age, sex, total cholesterol, diabetes, hypertension, dyslipidemia, previous heart disease, smoking, previous anti thrombotic or anticoagulant use, and white matter lesions.