Figure 6.
Biodistribution of iRGD-SSL-CLA-PTX in tumor-bearing mice.
Notes: When the tumor volume reached about 300 mm3, the tumor-bearing C57BL/6 mice were randomly assigned to one of three groups: group 1 was given intravenous (IV) CLA-PTX solution, group 2 was given IV SSL-CLA-PTX, and group 3 was given IV iRGD-SSL-CLA-PTX. All the CLA-PTX preparations were injected through the tail veins at a dose of 2 mg CLA-PTX/kg. After drug administration, the mice were killed at 1, 4, 8, 12, and 24 hours. The excised organs (heart, liver, spleen, lung, kidney, and brain) or tumors were collected. The content of CLA-PTX in each tissue was measured by high-performance liquid chromatography.
Abbreviations: SSL, sterically stabilized liposome; CLA, conjugated linoleic acid; PTX, paclitaxel.