Figure 7.

In vivo antitumor activity of iRGD-SSL-CLA-PTX.

Notes: When the tumor volume reached about 100–150 mm³, the tumor-bearing C57BL/6 mice were randomly assigned to one of four groups (each groups contained six animals): group 1 was given intravenous (IV) physiological saline as a control, group 2 was given IV CLA-PTX solution, group 3 was given IV SSL-CLA-PTX, and group 4 was given IV iRGD-SSL-CLA-PTX. All the CLA-PTX preparations were injected through the tail veins at a dose of 2 mg CLA-PTX/kg on days 7, 9, 11, 13, and 15. Throughout the study, mice were weighed and tumors were measured with calipers twice a week. Tumor volumes were calculated from the formula: V = length (cm) × width (cm²) ×0.5236. **P<0.01 versus physiological saline group as control; ^##P<0.01 versus CLA-PTX solution group; ^&&P<0.01 versus SSL-CLA-PTX group.

Abbreviations: SSL, sterically stabilized liposome; CLA, conjugated linoleic acid; PTX, paclitaxel.