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. 2014 Jun 24;9:3037–3056. doi: 10.2147/IJN.S61273

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© 2014 Baldi et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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Schematic representation of all the major steps for synthesis of Fe₃O₄-1-PNPs-hEGFR-^99m Tc. Structures of the ligand ethyl 12-(hydroxyamino)-12-oxododecanoate 1 and PLGA-b-PEG-COOH copolymer are reported in the blue frame.

Abbreviations: PLGA, poly(D,L-lactide-co-glycolide); hEGFR, human epidermal growth factor receptor; PNPs, polymeric nanoparticles; PEG, poly(ethylene glycol).