Table 3. Relationship Between Hypotension and Cerebral Perfusion Pressure Thresholds by Age Group.
| CPP Thresholds | Hypotensiona | Relative Risk (95% CI) | pb | |
|---|---|---|---|---|
|
| ||||
| No (n = 1,481) | Yes (n = 593) | |||
| 0–11 yr old | ||||
| n | 96 | 24 | ||
| CPP-H eventsc | 70 (86.4) | 11 (13.6) | Reference | |
| CPP-B eventsd | 19 (65.5) | 10 (34.5) | 2.54 (1.21, 5.34) | 0.01 |
| CPP-L eventse | 7 (70.0) | 3 (30.0) | 2.21 (0.74, 6.60) | 0.18 |
|
| ||||
| 12–17 yr old | ||||
| n | 152 | 45 | ||
| CPP-H eventsc | 49 (86.0) | 8 (14.0) | Reference | |
| CPP-B eventsd | 71 (80.7) | 17 (19.3) | 1.38 (0.64, 2.98) | 0.41 |
| CPP-L eventse | 32 (61.5) | 20 (38.5) | 2.74 (1.32, 5.68) | 0.004 |
|
| ||||
| ≥ 18 yr old | ||||
| n | 1,233 | 524 | ||
| CPP-H eventsc | 621 (73.4) | 225 (26.6) | Reference | |
| CPP-B eventsd | 480 (71.2) | 194 (28.8) | 1.08 (0.92, 1.27) | 0.34 |
| CPP-L eventse | 132 (55.7) | 105 (44.3) | 1.67 (1.39, 2.00) | < 0.0001 |
CPP = cerebral perfusion pressure, CPP-H = high CPP threshold, CPP-B = total time between CPP threshold, CPP-L = total time below the low CPP threshold.
a
SBP < 65 mm Hg for 0–1 yr old, < 75 mm Hg for 1–5 yr old, < 80 mm Hg for 6–11 yr old, and < 90 mm Hg for > 12 yr old.
b
Calculated from chi-square test.
c
CPP > 40 mm Hg for 0–5 yr old, > 50 mm Hg for 6–11 yr old, and > 60 mm Hg for > 12 yr old.
d
CPP 30–40 mm Hg for 0–5 yr old, 35–50 mm Hg for 6–11 yr old, and 50–60 mm Hg for > 12 yr old.
e
CPP < 30 mm Hg for 0–5 yr old, < 35 mm Hg for 6–11 yr old, and < 50 mm Hg for > 12 yr old.