Table 4. Relationship Between Elevated Intracranial Pressure and Cerebral Perfusion Pressure Thresholds by Age Group.
| CPP Thresholds | Elevated Intracranial Pressurea | Relative Risk (95% CI) | pb | |
|---|---|---|---|---|
|
| ||||
| No (n = 1,292) | Yes (n = 782) | |||
| 0–11 yr old | ||||
| n | 70 | 50 | ||
| CPP-H eventsc | 62 (76.5) | 19 (23.5) | Reference | |
| CPP-B eventsd | 7 (24.1) | 22 (75.9) | 3.23 (2.08, 5.04) | < 0.0001 |
| CPP-L eventse | 1 (10.0) | 9 (90.0) | 3.84 (2.46, 5.98) | < 0.0001 |
|
| ||||
| 12–17 yr old | ||||
| n | 91 | 106 | ||
| CPP-H eventsc | 53 (93.0) | 4 (7.0) | Reference | |
| CPP-B eventsd | 30 (34.1) | 58 (65.9) | 9.39 (3.61, 24.45) | < 0.0001 |
| CPP-L eventse | 8 (15.4) | 44 (84.6) | 12.06 (4.65, 31.24) | < 0.0001 |
|
| ||||
| ≥ 18 yr old | ||||
| n | 1,131 | 626 | ||
| CPP-H eventsc | 783 (92.6) | 63 (7.5) | Reference | |
| CPP-B eventsd | 283 (42.0) | 391 (58.0) | 7.79 (6.09, 9.96) | < 0.0001 |
| CPP-L eventse | 65 (27.4) | 172 (72.6) | 9.75 (7.59, 12.52) | < 0.0001 |
CPP = cerebral perfusion pressure, CPP-H = high CPP threshold, CPP-B = total time between CPP threshold, CPP-L = total time below the low CPP threshold.
a
Intracranial pressure > 20 mm Hg for 0–1 yr old and > 25 mm Hg for > 1 yr old.
b
Calculated from chi-square test.
c
CPP > 40 mm Hg for 0–5 yr old, > 50 mm Hg for 6–11 yr old, and > 60 mm Hg for > 12 yr old.
d
CPP 30–40 mm Hg for 0–5 yr old, 35–50 mm Hg for 6–11 yr old, and 50–60 mm Hg for > 12 yr old.
e
CPP < 30 mm Hg for 0–5 yr old, < 35 mm Hg for 6–11 yr old, and < 50 mm Hg for > 12 yr old.