Table 2.

Trial design and time line of the clinical study.

Screening	Trial Period
Visit 1	Visit 2	Visit 3	Visit 4	Visit 5
•Subject Enrollment •Supplementation with placebo •Pre-randomization placebo-run-in period	•Randomization •Supplementation •Data collection*	Data collection	Data collection	Data collection
Placebo-run-in 1 month	0 (baseline)	1 month	2 months	3 months

^*Overnight fasting (12 hours) blood samples, anthropomorphic data, record of daily insulin use and blood glucose levels were collected at each visit.