Table 1.
Criteria of immunohistochemical evaluation
| Protein | Scoring system | Cut-off | Staining pattern |
|---|---|---|---|
| ER |
H-Score |
≥1% |
N |
| PgR |
H-Score |
≥1% |
N |
| HER2 |
0-3 |
>10% |
M |
| p53 |
SQ |
>10% |
N |
| Ki67 |
SQ |
≥14% |
N |
| EGFR |
0-3 |
>1% |
M |
| CK5 |
SQ |
any |
C |
| CK14 |
SQ |
any |
C |
| CK17 |
SQ |
any |
C |
| CK8/18 |
SQ |
any |
C |
| Vimentin |
SQ |
any |
C |
| alphaB-crystallin |
Neg, W, S |
>30 |
C |
| BRCA1 | H-Score | >100 | N |
H-Score, histoscore; N, nuclear; M, membranous; C, cytoplasmic; SQ, semi-quantitative; Neg, negative; W, weakly positive; S, strongly positive.