Table 7.
Univariate Cox regression analysis for all examined markers in terms of DFS and OS
| |
DFS |
|||
|---|---|---|---|---|
| HR | 95% CI | Wald’s p | ||
|
Parameter |
Category vs. the reference |
|
|
|
|
BRCA1
mutation status |
Mutated |
1.68 |
(0.59-4.80) |
0.33 |
|
BRCA1 protein expression
|
Positive |
0.99 |
(0.65-1.51) |
0.95 |
|
alphaB-crystallin |
|
|
|
0.79 |
| |
Weakly positive |
1.02 |
(0.72-1.45) |
0.91 |
| |
Strongly positive |
1.14 |
(0.77-1.69) |
0.50 |
|
alphaB-crystallin (strongly positive vs. weakly positive/negative) |
Strongly positive |
1.14 |
(0.77-1.68) |
0.51 |
|
p53
protein expression
|
Positive |
1.21 |
(0.97-1.50) |
0.088 |
| |
OS |
|||
| |
HR |
95% CI |
Wald’s p |
|
|
Parameter |
Category vs. the reference |
|
|
|
|
BRCA1
mutation status |
Mutated |
1.75 |
(0.52-5.86) |
0.36 |
|
BRCA1 protein expression
|
Positive |
0.95 |
(0.57-1.58) |
0.86 |
|
alphaB-crystallin |
|
|
|
0.14 |
| |
Weakly positive |
0.98 |
(0.65-1.49) |
0.94 |
| |
Strongly positive |
1.52 |
(1.00-2.31) |
0.050 |
| alphaB-crystallin (strongly positive vs. weakly positive/negative) |
Strongly positive |
1.52 |
(1.01-2.30) |
0.046 |
| p53 protein expression | Positive | 1.24 | (0.98-1.65) | 0.066 |
HR, hazard ratio; CI, confidence interval.