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LR signaling pathways. Shp2, tyrosine phosphatase; IRS, insulin receptor substrate; STAT3, signal transducers and activators of transcription 3; SOCS, suppressor of cytokine signaling; PTP1B, protein tyrosine phosphatase; NPY, neuropeptide Y; AgRP, agouti-related protein. [Color figure can be viewed in the online issue, which is available at wileyonlinelibrary.com.]
