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Leptin–brain melanocortin system interaction. Schematic representation of the metabolic and cardiovascular effects of the leptin–melanocortin system pathway. CNS, central nervous system; Na, sodium; MC4R, melanocortin-4 receptor; POMC, proopiomelanocortin; SNS, sympathetic nervous system. [Color figure can be viewed in the online issue, which is available at wileyonlinelibrary.com.]
