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. Author manuscript; available in PMC: 2014 Jul 1.
Published in final edited form as: Lab Invest. 2011 Aug 8;91(11):1624–1633. doi: 10.1038/labinvest.2011.115

Figure 3.

Figure 3

Constitutive active/androstane receptor (CAR)-dependent liver injury. (a) The serum levels of ALT, ALP, total bilirubin (T-Bil) and total bile acids (TBA) in mice fed with the DDC diet for14 days. (b) Real-time PCR for NTCP and OATP1mRNAs using total RNA isolated from microdissected centrilobular and periportal regions. The bars indicate the fold inductions (mean±s.d.) relative to their levels in total livers of the control diet-fed Car +/+ mice. * and #indicate a significant difference at P<0.01 in comparison with control diet and in comparison between Car +/+ and Car−/− mice, respectively.