Table 6. The distributions of fitted selection probabilities on the extended apoptosis model.

Molecule	Functions	Mean	SD
NFkB	= (∼I_kBa|∼I_kBe)	0.8354	0.0209
	= (∼I_kBa|∼I_kBe)|(C8a|C8a_2)	0.1646	0.0209
complex2	= complex1 & FADD	0.8480	0.1105
	= complex1 & FADD & RIP_deubi	0.1520	0.1105

The Boolean rules of two target molecules in the ‘extended apoptosis model’ and the parameter distributions of the top 500 fitted selection probabilities in terms of optimal cost are shown. A low standard deviation (SD) value comparing to the corresponding mean value indicates that model is sensitive to the parameter of the respective Boolean interaction. This information highlights the relevancy of the respective interaction within the context of study e.g., the case of nuclear factor kappa-B (NκFB) activation by Caspase 8 (C8a or C8a_2) together with the absence of nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor alpha and epsilon (IκBa and IκBe) inhibitions. In contrast, a high value of standard deviation comparing to the mean value as seen in the case of TNF receptor-1 signalling complex 2 (complex2) activation by deubiquitinated form of receptor associated receptor kinase 1 (RIP_deubi) suggests that the model might not be sensitive to the respective parameter in this study. The relevancy of this interaction within the context of apoptotic signalling in primary hepatocytes is therefore in question.